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doi: 10.1002/jcla.23969 30 AhmedSMahonyCBTorresAMurillo-SaichJKembleSCedenoMet al

High IDO activity, often linked with chronic inflammation, supports theories of increased kynurenine production

For example, in the mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), Coenzyme Q10 (CoQ10) attenuated the generation of oxidants, elevated striatal dopamine levels, and increased the number of striatal mitochondria, the synthesis rate of ATP, and the activity of striatal complex I [6]

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These three states were consistently observed across three independent experiments

However, it should be noted that hydrogen peroxide generated in the circulation will be rapidly detoxified by antioxidant enzymes present in erythrocytes, including catalase, glutathione peroxidase, and peroxiredoxin-2 (Guemouri et al., 1991