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Tired and stressed
Preclinical and clinical trials should be designed accordingly, with a focus on conditions where antioxidant therapy is more likely to yield therapeutic benefit
E.RoundsW.SmithZ

Oral cysteamine therapy has extended the time to kidney failure by approximately 7 years (to a mean of 16 years) and mitigates or prevents late complications of the disease
An obligately aerobic soil bacterium activates fermentative hydrogen production to survive reductive stress during hypoxia

Astrocyte function through the regulation of AQP4 levels could be a novel target for nutraceuticals [252]