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The logic is that local administration creates higher peptide concentrations at the relevant tissue

doi: 10.1016/j.jconrel.2014.04.048

Robert Fitridge Mechanisms of vascular disease: A textbook for vascular specialists , Adelaide, SA, Australia: Springer Nature, Discipline of Surgery, The University of Adelaide

Why GHK-Cu Works Better Systemically (Not Just Topically) While GHK-Cu is commonly found in serums and post-procedure products, systemic delivery allows it to work beyond the surface of the skin

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