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Specifically, linking ONs - such as antisense oligonucleotides (ASOs) or short-interfering RNAs (siRNAs)to proteins or peptides can enhance properties like cell-specificity and cellular uptake 6 , which remain significant hurdles for many ON therapeutics
The phosphorylation of histone H2AX was detected to evaluate the DNA damage related to behavioral activation therapy (BA) treatment, and CHE was further reported to increase the expression of gH2AX and regulate caspase-3 cleavage at different levels (Hammerov et al., 2011)
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363 Also, m-aconitase activity can contribute to the proliferation and migration of prostate cancer cells
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