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41 High-dose niacin (a form of vitamin B3) can cause flushing that could be confused with or aggravate rosacea

For example, for DON or AFM1 in urine the variations are relatively small, compared to FB1, where any given biomarker measure could reflect a 9-fold variation in the intake estimate for any given individual (see Table 11)

Allergic reactions, though rare, can also occur

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ajmalicine and tetrahydroalstonine showed higher binding affinities on alpha-2A, 2B, and 2C receptors, with K i values in the submicromolar range (K i = 1865 nM) than tetracyclic kratom alkaloids (K i values in the micromolar range)