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Forces that maintain the complex of substrate and bound substances include electrostatic interactions, hydrophobic interactions, and hydrogen bonding

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Increased movement of high amount of enzyme glutamate decarboxylase and diamine oxidase increases the production of GABA during stress situation (Wang et al

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Both metformin and pioglitazone were able to downregulate pro-inflammatory mediators in multiple brain regions, indicating a global anti-inflammatory effect

Ferreira N, Goncalves NP, Saraiva MJ, Almeida MR