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Pramlintide, the first human amylin analogue to receive regulatory approval, was designed, among other design features, using a triple substitution to introduce proline residues at positions 25, 28, and 29 (as in rat amylin) to avoid fibrillation

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Oncol Nurse Advis IM 47.Talevi A, Quiroga PAM (2018) ADME Processes in Pharmaceutical Sciences (Dosage, Design, and Pharmacotherapy Success)

However, rational optimization of these lipids remains challenging because of the complexity of LNP systems and the limited understanding of how lipid structure influences both efficacy and long-term safety

ii Collagen-driven