methionine increases glutathione metabolism in health and cancer: a nexus of diet and precision medicine Glutathione Metabolism - an overview

Suppressor of cytokine signaling (SOCS) 2, a regulatory cytokine and growth factor signaling in hepatocytes, can inhibit AILI by regulating pro-oxidative and inflammation-related mechanisms

Furthermore, the production of nucleotides supports the replenishment of the oxidized nucleotide pool and facilitates DNA repair

Vitamin B6 deficiency : Vitamin B6 (pyridoxine) is required for heme synthesis, being a cofactor for delta-ALA synthetase

against dextran sulfate sodium induced intestinal mucosal injury on mice

Maintaining adequate levels is key to promoting good health

Furthermore, lactate, as the main metabolic product of the acidic microenvironment, has concentration-dependent effects: low concentrations (510 mmol) may have anti-inflammatory and anti-apoptotic effects, while high concentrations (15 mmol) promote inflammatory factor expression and cell apoptosis (Schneider et al., 2012)