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This phosphorylates and inhibits GFPT1, thereby weakening YAP protein stability and the transcription of its downstream target gene FTH1, ultimately promoting ferritinophagy, lipid peroxidation, and enhanced ferroptosis susceptibility (50)

Regardless, targeted measurements of the carnitine pool offer insights into the metabolic derangement of sepsis that provide opportunities to develop new pharmacologic interventions and prognostic biomarkers

10.1016/j.jhep.2020.06.036 15

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