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For the analysis of lipids in the serum from WT, Gclc L-KO, Nrf2 L-KO, and L-DKO mice, the methods were the same with the following exceptions: MS2 scan conditions were applied in positive mode, the scan range was from m/z 120-1000, and the resolution was 120,000 for MS

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Thereby, individual differences in metabolic or proteolytic activity, differences in splenic function, or variation in expression of (compensating) PK isoenzymes and the activity of other compensating pathways may contribute to the disease phenotype, as well as epigenetic factors and co-inheritance of other (red cell) diseases (Bianchi and Fermo, 2020)