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On the other hand, animal models suggest that a simple genetic defect (such as TREX1 deficiency) may be insufficient to induce full tissue inflammation, often requiring an environmental 'second hit', indicating that its pathogenicity may be conditional rather than absolutely causative (217)
Mol Cell (2015) 59:298308
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Functional characterization of the new human GABAA receptor mutation 3(R192H)
Babaei, A., Asadpour, R., Mansouri, K., Sabrivand, A
