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Respiratory exposure to gliotoxin or ingestion of patulin increased the asthma-like phenotype in an animal model and additionally increased chronic airway inflammation [90]
Trials should co-primary mechanistic change (e.g., Prx cycling, 2-OH-E by DHE-HPLC, LIP de-quench) and clinical improvement, with biomarker gates for entry and adaptive dosing to respect where, when, how much. Pre-specified normalization (per protein/cell, oxygenation, m for mito-probes) and orthogonal controls (SOD/catalase, chelators, genetics) should be mandatory (Katerji et al
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58 Earlier studies found that iron overload in mice increases oxidative stress in bone, leading to changes in bone microstructure and mineral deposition properties, resulting in osteoporosis
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*Correspondence: Ravindra Pal Singh, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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