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Efficacy and safety of lenzumestrocel (neuronata-R(R) inj) in patients with amyotrophic lateral sclerosis (ALSUMMIT study): study protocol for a multicentre, randomized, double-blind, parallel-group, sham procedure-controlled, phase III trial

As muscle and nerve tissue have very high energy requirements, defective mitochondrial energy production may lead to an energy shortage during stress that affects nerve function, especially the autonomic nerves that control the gut

and CO work highlights a dose-dependent developmental signaling window

The workflow described in this study maps the identified metabolites to specific metabolic pathways, which can then be traced to the corresponding genes and species harbouring the genes, thereby facilitating the elucidation of functional contributions by the microbiota to the complex metabolite profile of the gut

In CuCP complex, which constitutes approximately 75% from the total copper pool (our data and 4,5 ), the copper ions are bound in protein interior, which makes them kinetically inert and practically nonexchangeable at physiological pH values even in the presence of high millimolar concentrations of powerful Cu(II)-chelating ligands like EDTA or DTPA

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