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4 Mitochondrial DNA: a key player and victim in HIV pathogenesis Mitochondrial DNA (mtDNA) occupies a dual role in HIV pathogenesis: it is both a target for viral-induced damage and a potent activator of innate immune pathways that drive chronic inflammation

Similarly, there are first examples for HOCl-based signaling: the extracellular action of HOCl in the induction of apoptosis in transformed cells has been termed the HOCl-signaling pathway (see [338] for a recent review)

10.1016/j.atmosenv.2011.12.062

The peptide also engages VEGFR2 (vascular endothelial growth factor receptor), promoting angiogenesis

BMJ 369, m1432

[DOI] [PMC free article] [PubMed] [Google Scholar] 119.Veling W., Pot-Kolder R., Counotte J., van Os J., van der Gaag M