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In general, high c-di-GMP levels reduce the expression and/or activity of flagella and stimulate the expression of various adhesins and biofilm-associated exopolysaccharides (EPSs)

To mix HCG, use a sterile diluent like bacteriostatic water or saline

Nature (2016) 540:58387.10.1038/nature20597 137 SesterDPSagulenkoVThygesenSJCridlandJALoiYSCridlandSOet alDeficient NLRP3 and AIM2 inflammasome function in autoimmune NZB mice

The 2024 Inflammopharmacology review compiled the most current GI-protection data set across more than two decades of research