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Unlike MSCs, which undergo senescence after a limited number of passages or with aging [59, 62], MSC-Exos do not exhibit signs of senescence and are more cost-effective and easier to produce at scale for clinical applications [63, 64]

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Polarized lighting images were performed on a fluorescence microscope (Olympus BX43, Tokyo, Japan) fitted with an analyzer (U-ANT, Olympus) and polarized (U-POT, Olympus)

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V., Wagner, T