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Pharmacological inhibitors such as NLRP3 antagonists and caspase-1 inhibitors show promise in preclinical models but require further clinical validation

AA metabolites were remarkably elevated in psoriatic lesions compared to healthy individuals and non-lesioned skin samples

protocol shows why short trials are easy to misread

In this work we demonstrated that in the case of FH loss, this activity is mediated by fumarate, at least in part via GSH succination

Collectively, these studies highlight the positive health effects of ketogenic diets, particularly in enhancing longevity and cognitive function in the elderly

Chan et al., 2022)