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These recommendations are formulated based on expert opinion, available literature, and indirect evidence and as such are not amenable to GRADE methodology

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The aggregation of proteins leads to the formation of highly ordered pathogenic fibrillar aggregates, called amyloid fibrils 19,20 , which are implicated not only in HCCAA but also in a wide range of neurodegenerative diseases such as Alzheimers, Parkinsons, CreutzfeldtJacobs, and Huntingtons disease 20