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While urinary excretion of VC metabolites (oxalate, threonate) maintains systemic balance, prolonged deficiency ( ShacterEet alAscorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

An aliquot of supernatant was removed and assayed for protein concentration using the BCA protein assay (Pierce Scientific, Rockford, IL)

An additional study examining the combined effect of i.v Vit-C (1000 mg/d) and chemotherapy (Gemcitabine, carboplatin) on triple-negative breast cancer (TNBC) discovered that some cases experienced complete remission (CR), while other cases experienced partial remission (PR) and stable disease (SD) after treatment, when compared to the control group

OADs: Oral antidiabetic drugs