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In myeloid cells such as macrophages and DCs, FXR activation typically represses pro-inflammatory gene expression (often via NF-B inhibition) and can promote M2 polarization (81)

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doi: 10.1002/mnfr.202300840

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Tumor cells and inflamed cells have high ROS levels, causing high GSH levels to maintain redox homeostasis

Circulation Research, 120(7), 1183-1196