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Infection outcome and cytokine gene expression in Brugia pahangi -infected gerbils ( Meriones unguiculatus ) sensitized with Brucella abortus

Protein Cell 2021;12:599-620

TGKIM`tAd$m i*LH6$[AXaAANi`L&aZ i"B!2KB"*U4 M&l'M0A ee \4M0B! h0DJs+IM Aa0M4 'ih00QsaDDG $AD/ & (B" a "0+0 !hF $0Q 2Lh0 "

To increase aqueous solubility of the compounds to facilitate structural studies, the cycloheptyl substituent in TGR uncompetitive inhibitor 8 was replaced with a sugar moiety, resulting in compound 9 , a noncompetitive inhibitor and thus capable of binding the enzyme in absence of NADPH