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The model is also consistent with published results that show that female mice are less susceptible than males to hepatotoxicity due to acetaminophen overdose and suggests that this might also be true for humans, though the human epidemiological data are contradictory.

Endoscopic biopsies of colon mucosa werecollected from normal subjects, from macroscopicallynormal tissue of patients with inactive and active ulcerative colitis, and from inflamed tissue ofpatients with active ulcerative colitis

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We propose patients who pause treatment may have testing repeated after 2 weeks, while those with resolving aminotransferase elevations may reinitiate omaveloxolone with stepwise dose titrations and testing every 2 weeks for 3 months