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4.6.10 Excitotoxicity Depolarization of upper motor neurons triggers glutamate release into the synapse, activating post-synaptic glutamate receptors (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, AMPA, and N-methyl-D-aspartate, NMDA) [311]

Athletic governing bodies such as USADA and WADA list BPC-157 and TB-500 as prohibited substances under the 2025 Prohibited List

This characteristic makes cardiac glycosides good candidates as senolytics to target senescent cells, due to their role as specific inhibitors of the NA + /K + ATPase pump

Hosoki, S

DH: Software, Visualization, Writingoriginal draft

The adaptation ratio was calculated as the ratio between the first and the last interspike interval during a depolarizing current step 60 pA above the rheobase