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Introduction Reactive oxygen species (ROS), that are free radicals and non-radical molecules [1], are key components of the signaling pathways network, and act as main regulators of cellular responses and cell physiology of plant to environmental factors [2]

Opioid receptors reveal a discrete cellular mechanism of endosomal G protein activation

This was explained as ATZ causes oxidative stress by forming ROS 71 , lipid peroxidation and antioxidant depletion 72

Nonetheless, these studies have provided us with ever more precise insights into the molecular mechanisms that account for CDDP resistance, at least at the cell-intrinsic level

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