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We selected predicted immunogenic neoantigens using OncoPept VAC and tested wildtype and mutant pairs of peptides for their immunogenicity in a CD8 + T cell activation assay

Recent research has demonstrated that pH levels in the TME significantly impact immune cell function, cytokine secretion, and ammonium metabolism reprogramming, which may contribute to the decreased pH value in the TME (269)

We therefore strongly recommend that neuroimaging studies of ME/CFS consider this area (at the dorsal surface of brainstem just inferior to pons) as an a priori region of interest

However, studies have proposed NO to represent a double-edged sword with its overproduction leading to a multitude of NO by-products implicated in mutational events and carcinogenesis

FIGURE 3 6.1 Endothelial cell metabolism in health 6.1.1 Glycolysis The main energy source accounting for around 80% of the total ATP production in ECs is glycolysis (Figure 3)