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Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility
During the 7-day treatment schedule, MP-13 maintained stable antinociception without tolerance development, as evidenced by the unchanged microglial cell count in the periaqueductal gray, indicating that chronic exposure did not trigger neuroinflammatory adaptationa process in which microglia become activated, release pro-inflammatory cytokines, and contribute to opioid tolerance

The authors reported that IR treatment of NBS1-K388R-mutant cells delays DNA repair compared to control cells, which is associated with reduced formation of BRCA1 and RAD51 foci
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