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doi:10.3389/fphar.2021.627533

However, IF receptors max out at absorbing only about 1 to 2 micrograms per dose, making standard pills highly inefficient for correcting severe cellular deficiencies

If your B12 deficiency has caused nerve damage, you may experience symptoms such as: Numbness or tingling (pins and needles) in your hands or feet Difficulty with balance, coordination, or walking Significant memory loss, confusion, or cognitive changes If you have any of these neurological manifestations, intramuscular injections remain the absolute gold standard for treatment [18] [19]

Rubbing can cause bruising and may spread the medication outside the intended injection zone