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Additionally, two-year safety data from the STEP 5 trial shows that while gastrointestinal events occurred in 82% of participants at some point during the study, most of these events were concentrated in the initial 6 months, with frequency and severity declining markedly in long-term treatment

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Additionally, recapitulating their presumed neural crest origin, nevus cells can show aberrant lines of differentiation, and some lesions may have excess adipose tissue and other mesenchymal elements, including cartilage and aberrant vasculature (Fig

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