glutathione skin lightening topical randomized controlled trial as a whitening agent: Facts, myths, evidence and controversies PDF] Glutathione for skin lightening:

A key practical limitation is the difficulty of maintaining long-term adherence to ketogenic interventions, which may reduce their feasibility and sustainability in dermatological practice

Wu et al, 2023

70 TaddeiSCaraccioNVirdisADardanoAVersariDGhiadoniLet al

138.Makkar B, Agarwal S, Vishwanathan V, Sahay R, Maheshwari A, Sharma JK, Jethwani P, Ghosh S, J A, Sreenivasamurthy L, Chawla M, Singh NK, Shunmugavelu M, Gupta A, Kesavadev J, Parikh R, Chawla R, Seshadri K, Saboo B, Virmani A, Deshpande N, Gupta S, Kapoor N

Mechanistically, autoantibodies directed against AMPA-Rs and NMDA-Rs decrease the numbers of the cell-surface receptors [63] and anti-AMPA-RAb may act as agonists and increase cell excitability [66]

however, these levels promptly returned to baseline after prednisone discontinuation followed by suppressed GH levels