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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Krisanits B.A., Kaur B., Fahey J.W., Turner D.P

A number of risk factors exacerbate AD, including folate and vitamin B 12 deficiency

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Additionally, since the longer chain humectants will sit on the top of the skin and bind reversibly to smaller humectants (via whats called hydrogen bonding), the smaller humectants will gradually absorb into the skin over a longer period of time, like an extended release humectant system, so the plumping and hydration effects last longer