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Infante JR, Pacheco C, Torres-Avisbal M, et al

The HMGB1/5HT7R/Nrf2/xCT/GPX4 pathway was found to promote ferroptosis of M2 microglia in transient middle cerebral artery occlusion (tMCAO) mice, which promoted ischemic brain injury and depressive-like behaviors

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Thus, research is focused on the development of novel treatment approaches

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