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To investigate the mutational profile of the mutations resulting from each gene deficiency, regression with the full model was repeated on each of the six substitution types as well as on the 96 trinucleotide mutation classes, using the total burden of each mutation type as the response variable

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To view a copy of this licence, visit About this article Cite this article Coden, K.M., Nguyen, D.K.K., Moorhead, R