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We have previously shown that blocking of CPT1 by an irreversible CPT1 antagonist or by genetic inhibition show clinical-relevant effects in in vivo models of neurodegenerative diseases, diminishes inflammation, demyelination oxidative stress and increases mitochondrial biogenesis 20,22,23,24

Implementation of the L-carnitine biosynthesis pathway was guided by the recently developed L-carnitine biosensor, which allowed the identification of the enzymes and their assembly into an optimized biosynthetic pathway in the form of an enzyme cascade

This mutation is associated with the fatal neonatal form of CPTII deficiency [2]

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For triglycerides, both DHA-only and the 1.7:1 EPA: DHA formulation showed dose-dependent reductions, with DHA-only demonstrating a steeper and more effective slope, reaching the target effect size of 0.8 at higher doses