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Figure 2 Regulation of Acetyl-CoA/CoA Ratio Under physiological conditions, carnitine can buffer excess acetyl-CoA in the mitochondria via the formation of acetyl-carnitine (33), which requires the presence of carnitine acyltransferase and carnitine acylcarnitine translocase

L.et al (2018)

CrAT uses short-chain acyl groups (C1-C4) as substrate, whereas COT uses both medium and long-chain fatty acids (C5-C12) having a preference for medium chain acyl-CoA

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