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This pilot study suggest that the nasal drops may be used as an alternative to injections because two thirds of ME/CFS patients reported a positive effect, accompanied by an increased number of steps, improvement of the RAND-36 physical functioning scale and the CIS20r fatigue scale, and a significant increase in serum vitamin B12 levels

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Even though some micronutrients, such as Ca, Mg, Fe, folic acid, and Vit D, have been shown by some researchers to exert a protective effect in sleep [14, 15, 33, 34] while K reportedly has the opposite effect [35], our study did not find any associations between these micronutrients and insomnia