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Specifically, it is the gliadin component of gluten that is responsible for stimulating the immune-mediated destruction of the intestinal barrier (Smyth 2017)

J Sci Food Agric 91:578585

[DOI] [PubMed] [Google Scholar] 78.Ilic S., Drmic D., Zarkovic K., Kolenc D., Brcic L., Radic B., Djuzel V., Blagaic A.B., Romic Z., Dzidic S., et al

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Further, RA patients with serious infections before the initiation of TNF- inhibitor therapy were not at increased risk of subsequent serious infection and the hospitalization rate was comparable between patients continuously treated with the same TNF- inhibitor and patients who switched to another TNF- inhibitor, or even to a different mode of action [54]
