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doi: 10.2174/1381612823666161118144216

This can be further extended

While each peptide has an independent body of preclinical literature, no published peer-reviewed study has examined this specific combination, and the theoretical synergy between their complementary mechanisms remains unvalidated by controlled experimental evidence
Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis

And in some cases can cause some receptor internalization or desensitization as well, although not as potently as Hexarellin

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