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Acute glycolytic flux generates lactate that acidifies the microenvironment, proton loads inactivating sirtuin deacetylases to impair peroxisome proliferator-activated receptor gamma coactivator 1 alpha-mediated mitochondrial biogenesis [71] while activating calcium-independent phospholipase A 2 to liberate arachidonic acid [72]

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doi: 10.1200/JCO.2016.67.9258 137 PostowMAHamidOCarvajalRD

Vitamin C is a hydrophilic molecule and has negative charge at physiologic pH

Evolution and diversity of the ema families of the divergent equid parasites, Theileria equi and T

It is likely that as the condition worsens, so the probability of identifiable biomarkers for the disease increases, making it crucial to study severely ill patients