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Description
Cigarette smoke (CS) exposure exacerbates these issues, leading to increased mtROS and cellular damage
The extrinsic pathway is mediated by the interaction of FASL (Fas ligand) and FAS (Fas cell surface death receptor), which engages the adaptor molecule FADD (Fas associated via death domain) to recruit and activate CASP8 (caspase 8) [74]

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Toxicol Pathol (submitted as companion paper)

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