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Neutralizing antibody production was detected in some patients plasma during drug treatment

Innovative methodologies with classified or pattern-based randomization, core-plus-module treatment designs, and hybrid endpoints incorporating clinical outcomes with biomarker data might help to bridge the gap between traditional practice and evidence-based medicine

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G., Whittaker, R

The current American Academy of Dermatology position published in 2010: Current evidence is insufficient to prove either an association or a causal relationship between isotretinoin use and inflammatory bowel disease in the general population

SHOU, M