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Figure 2 illustrates possible study schema for an FIH study with multiple objectives

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This metabolic shift in LS-mediating glycolysis reduces eNOS O-GlcNAcylation, thereby enhancing eNOS phosphorylation and NO production [205]

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GSH has also been shown to reduce levels of TNF-, a proinflammatory cytokine found upregulated in COVID-19 which triggers cytokine release syndrome (CRS) and facilitates SARS-CoV-2 binding with angiotensin-converting enzyme 2 (ACE2) [19,20]

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Radiation-induced liver injury and hepatocyte senescence

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assay for transposase-accessible chromatin with sequencing) and importantly can also integrate mutational profiling (single nucleotide variations and structural variants) 112 and/or tracking of clonal dynamics based on mitochondrial marker mutations (TARGET-seq, 113 GoT [genotyping of transcriptomes] 114 and MutaSeq 115 )

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