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Out of 41 RCTs, 39 studies have shown a significant lowering effect of L-carnitine supplementation on FBG (mg/dl) (16, 17, 23, 43, 4569, 7180), 19 studies on serum insulin (pmol/l) (16, 43, 44, 51, 5355, 57, 59, 61, 63, 68, 7176, 80), 20 studies on serum HbA1c (%) (16, 17, 23, 45, 48, 49, 5355, 57, 58, 61, 63, 66, 67, 71, 74, 77, 79, 80), and 17 studies on HOMA-IR (43, 44, 49, 50, 5457, 59, 61, 63, 68, 7073, 75)

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It potently protects sperm mitochondria against electron transport chain-induced ROS through some mechanisms including radical scavenging, iron ions chelating, and increasing expression of mitochondrial antioxidants such as superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and glutathione peroxidase (GPx), maintains sperm mitochondrial membrane and DNA integrity, and finally modulates the sperm cell apoptotic signaling

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