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Low glutathione levels can lead to increased oxidative stress, impaired detoxification, and a higher susceptibility to various health conditions, including kidney disease

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Although the synthesis of triazole-based PROTACs follows the principles of green chemistry, these compounds have low solubilities and are challenging from a pharmaceutical industrial viewpoint due to the difficulty of scale-up

Li MS, Adesina SE, Ellis CL, Gooch JL, Hoover RS, Williams CR (2017) NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage

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Free Radic Biol Med (1998) 25(4-5):43456