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The concentration of MOTS-c influenced the expressions of these genes, and knockdown of TGF- or SMAD7 partially reversed the increase in collagen expression, indicating the involvement of the TGF-/SMAD pathway

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Sikiric, P., Petek, M., Rucman, R., etal

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To overcome this limitation, a clinical study combines decitabine and tetrahydrouridine (THU), a cytosine deaminase inhibitor, as a therapeutic strategy for inducing HbF (ClinicalTrials.gov Identifier: NCT01685515)

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