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Compounds showing 10-fold improvements in maze learning or complete reversal of cognitive deficits in mice consistently fail to demonstrate meaningful clinical benefit

Rodencal, J

Another interesting finding related to NSI-189 is the significant improvement compared with placebo in cognitive symptoms, as measured by the CPFQ

doi: 10.1136/gutjnl-2023-331117 39 HuangJPanHSunJWuJXuanQWangJet al

Patient acceptance: Limited real-world efficacy data and insurance coverage disparities hinder patient acceptance of novel nanotherapies

Verapamil could probably induce a specific conformational change where the G1228 plays an important role