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Furthermore, E362 is nearby C326 and likely keeps the cysteine reduced for covalent attack of the aldehyde, as evidenced by the reduced activity upon its substitution (E362A)

It is thus no wonder that cancer cells with metastatic potential possess higher cancer stemness, and cancer cells with the organotropism for highly oxidative organs such as brain and lung are more stem-like and more malignant as compared with their peers containing more bulk tumor cells

Sepsis-induced immunosuppression: Mechanisms, diagnosis and current treatment options

The entrapment of [14C]ascorbic acid in human erythrocytes

Semin Hematol 26:105113 Williams RJP (1982) Free manganese(II) and iron(II) cations can act as intracellular cell controls

Voutsinos-Porche et al., 2003