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A GWAS in male Chinese participants revealed four loci (MSX2, CXCR5, PRKCE and MARCKS) associated with the presence of tophi, introducing novel and currently insufficiently explored genetic associations with gout

Brown DR, et al

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Due to recent results on changes in cell signaling and neuronal plasticity, it may be important to identify the symptoms and treat them as early as possible to avoid formation of new and functionally disturbing neuronal circuits due to overstimulation of neuronal-glial units

Maintenance doses follow every 4-6 weeks