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These differences in GST type and multiplicity, as well as residue changes that impact the secondary and tertiary structure of the cat and dog GST proteins, affect substrate selectivity and catalytic efficiency

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But being present in a cancer cell is not the same as driving the cancer

This unbalanced regulation of the glutathione oxidation/reduction cycle indicates the existence of an alternative pathway to regenerate GSH from GSSG to maintain a stable GSSG/GSH ratio

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