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Berberine (from Berberis species) is an isoquinoline alkaloid with broad neuroprotective mechanisms (antioxidant, antiapoptotic, antiinflammatory) [43]
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doi: 10.1111/ans.19155 87 ThatipamalaPNoelJEOrloffL
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They maintain a healthy balance between producing and eliminating such harmful molecules
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doi: 10.1111/apha.12365 37 MarcinkiewiczJKontnyE
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Possibly, in the absence of GPx-1, accumulated oxidants may oxidatively damage proteins involved in signaling to suppress survival responses
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