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reported lower GPX3 activity in individuals who died from CVDs compared to controls, revealing a linear and inverse relationship between serum GPX3 activity and CVDs mortality in individuals with low HDL, encompassing conditions such as coronary heart disease, other atherosclerotic diseases, and stroke [64]

BMC Nephrol 21:118

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Observed mechanisms include direct neuronal damage, disruption of key neurotransmitter pathways such as AChE activity, induction of cellular stress responses, and alterations in both locomotor and spontaneous activity patterns, particularly in Drosophila

T., & DelGiorno, K